Hey!
I looked it up for you and found a post on the SCS forum that might help you.
It mentions the following;
Game change detected is game error, when something went wrong with cargoes (or other stuff). What might happened, is:
1. wrong version of speditor. Make sure, you are using proper version to proper game version
2. mods, that cannot be handled well by Speditor
3. Not properly added cargoes to cargo.fil
4. other issue, that is not discovered yet.
you can remove error.log file from Speditor Folder, start Speditor, add cargo as usual. If game throws that error again, please post me content of error.log file. This might help to discover what is going on. Without additional details, I cannot help much.
https://forum.scssoft.com/viewtopic.php?t=199114&start=1070
I put the link so you can see the post and the other comments there