If we talk about difficult in the sense of many people and that at any time can crash into you. The route would be Calais-Duisburg, and if you have promods you can try the kirkenes route, there are quite a few "difficult" routes but it depends on what you really want.
This depends a lot on the components you have in your pc, but I advise you to lower the resolution, for example you could use 1280x720, it is a good resolution and would increase your fps.
It is also understandable because of the amount of reports they have on the web. For this reason, we hardly see them on the C-D route. But I like the idea of them looking for strategies to be more in-game.
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